From Formulation Concept to Clinical Evaluation
Bakunova provides end-to-end formulation development and evaluation services for cosmetic actives and advanced skincare products. Using our proprietary Xnova™ technology platform, we develop optimized formulations designed to improve active-ingredient stability, solubility, skin delivery, bioavailability, safety, and performance.
Integrated formulation development, scientific evaluation and clinical validation.

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Formulation Development
We develop customized formulations based on the physicochemical properties, biological activity, and intended application of each active ingredient.
Our formulation capabilities include:
Characterize quality, biological activity, safety and clinical performance.
Each evaluation programme is aligned with the formulation, active ingredient, intended application, and product-development objective.
Physicochemical Characterization
We evaluate the critical quality attributes of developed formulations to ensure stability, consistency, and product performance.
Our services include:
- Particle size and size distribution
- Zeta potential
- Encapsulation efficiency
- Active-ingredient content
- Solubility and dissolution
- pH, viscosity, and appearance
- In vitro release studies
- Permeation and skin-deposition studies
- Accelerated and long-term stability studies
In Vitro Biological Evaluation
Our cell-based studies assess the biological activity, safety, and efficacy of formulations before advancing to more complex testing.
Evaluation capabilities include:
- Cytotoxicity and cell viability
- Anti-inflammatory activity
- Antioxidant activity
- Collagen and elastin support
- Anti-ageing activity
- Melanogenesis and pigmentation studies
- Antimicrobial and anti-acne activity
- Cellular uptake and mechanism-of-action studies
Ex Vivo Biological Evaluation
We use physiologically relevant skin models and biological tissues to understand formulation behaviour and performance under conditions that closely represent human skin.
Our ex vivo services include:
- Skin penetration and permeation
- Epidermal and dermal deposition
- Barrier-function assessment
- Histological evaluation
- Biomarker analysis
- Comparative product-performance studies
Safety and Performance Evaluation
Each formulation is evaluated through a structured testing programme designed to establish product safety, functional performance, and suitability for its intended application.
Testing may include:
- Skin irritation and sensitization
- Phototoxicity assessment
- Ocular irritation screening
- Compatibility studies
- Performance benchmarking
- Reference-product comparison
Clinical Evaluation
Bakunova supports scientifically designed clinical studies to validate product safety, tolerability, and consumer-relevant benefits.
Clinical evaluation may include:
- Dermatological safety assessment
- Skin hydration and barrier improvement
- Fine-line and wrinkle reduction
- Skin firmness and elasticity
- Pigmentation and skin-tone improvement
- Acne and sebum-control assessment
- Consumer-perception studies
Integrated Development Approach
From active-ingredient selection and formulation design to physicochemical characterization, biological testing, and clinical validation, Bakunova provides a complete development pathway for creating safe, stable, and high-performance cosmetic products.
From formulation concept to clinical evaluation.
Discuss your cosmetic active, formulation prototype, testing requirement, or clinical-development objective with Bakunova.
